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|Type:||Artigo de periódico|
|Title:||The Impact of Cigarette Smoke Inhalation on the Outcome of Enamel Matrix Derivative Treatment in Rats: Histometric Analysis|
|Abstract:||Background: Tobacco use is the most significant risk factor of periodontal disease. Clinical evidence has demonstrated that tobacco may negatively influence the results after surgical and non-surgical periodontal therapy. Enamel matrix derivative (EMD) have been used in periodontal regenerative procedures resulting in improvement of clinical parameters. The effect of EMD in the presence of tobacco compounds is unclear. Thus, the aim of the present study is to evaluate the impact of cigarette smoke inhalation (CSI) on the results of EMD treatment. Methods: Twenty-two Wistar rats were assigned to two groups: Group 1, CSI (n = 11); Group 2, non-exposed (n = 11). Thirty days after initiation of CSI, fenestration defects were created at the buccal aspect of the first mandibular molar. The study followed a split-mouth design. After the surgeries the defects were randomly assigned to two subgroups: non-treated control and treated with EMD. The animals were sacrificed 21 days later and the percentage of defect fill, density of newly formed bone, and new cementum formation were histometrically assessed. The number of osteoclasts was determined by tartrate-resistant acid phosphatase. Results: CSI was associated with less bone density compared to the non-exposed group. EMD provided an increased defect fill and new cementum formation in both groups. The number of tartrate-resistant acid phosphatase positive osteoclasts was significantly higher in the CSI non-treated control group compared to the non-treated control of the non-exposed animals. Conclusions: EMD may provide increased defect fill and cementum formation in the presence or absence of CSI. However, tobacco smoke produced a detrimental effect on bone healing when density of newly formed bone was considered. J Periodontol 2010;81:1820-1828.|
enamel matrix proteins
|Editor:||Amer Acad Periodontology|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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