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Type: Artigo de periódico
Title: The Heck-Matsuda arylation of 2-hetero-substituted acrylates
Author: de Azambuja, F
Correia, CRD
Abstract: The Heck-Matsuda arylation of 2-aza and 2-oxo-substituted acrylates is described. Several reaction conditions were evaluated including the influence of solvents, temperature, catalysts, and stoichiometry. While the oxygenated system was successfully arylated in benzonitrile with Pd(2)(dba)(3) as catalyst, the aza-acrylate furnished methoxylated products. The methoxylated products were subjected to an elimination/reduction protocol to obtain the corresponding N,O-protected phenylalanine derivatives. A one-pot procedure for the preparation of phenylalanine derivatives from 2-aza-substituted acrylates is presented. (C) 2010 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2010.10.132
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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