Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73702
Type: Artigo de periódico
Title: The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns
Author: Bezerra, RMN
Marba, STM
de Castro, V
Saad, STO
Sales, T
Saad, MJA
Passini, R
Abstract: OBJECTIVE - We studied the association between the Gly972Arg polymorphism in insulin receptor substrate-1 (IRS-1) and birth weight in a population-based sample of Brazilian newborns. RESEARCH DESIGN AND METHODS - We studied 194 newborn children with adequate gestational age to identify the association between the Gly972Arg polymorphism and birth weight using PCR-restriction fragment length polymorphism analysis. RESULTS - The data showed that the birth weight was lower in the newborns with the Gly972Arg polymorphism in IRS-1 compared with control subjects (3.1+1 +/- 31.8 vs 3.373 +/- 80.3 g. P < 0.008). The results also showed that the frequency of this polymorphism was increased in newborns with a birth weight <3,000 g (P = 0.041). CONCLUSIONS - These results suggest that the genotype Gly972Arg may influence birth weight, reinforcing the hypothesis that genetically determined insulin resistance and/or reduced insulin secretion can result in impaired insulin-mediated growth in the fetus.
Country: EUA
Editor: Amer Diabetes Assoc
Rights: fechado
Identifier DOI: 10.2337/diacare.25.3.550
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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