Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73637
Type: Artigo de periódico
Title: The MIA-QSAR Method for the Prediction of Bioactivities of Possible Acetylcholinesterase Inhibitors
Author: Bitencourt, M
Freitas, MP
Rittner, R
Abstract: This paper describes the use of the multivariate image analysis-quantitative structureactivity relationship (MIA-QSAR) methodology, which is a method capable of relating chemical structures with their biological activities. This in silico method has been shown to be extremely reliable and provides excellent results, even compared to those obtained by costly and time-consuming methods. Here, a class of acetylcholinesterase inhibitors was studied and three new compounds exhibiting high estimated pIC50 values were found. They may be promising inhibitors for use in the treatment of Alzheimer's disease.
Subject: Acetylcholinesterase
Carbamates
MIA-QSAR method
Country: Alemanha
Editor: Wiley-v C H Verlag Gmbh
Rights: fechado
Identifier DOI: 10.1002/ardp.201200079
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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