Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/735
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.subject.otherHISTONE DEACETYLASE INHIBITORSen
dc.subject.otherT-CELL LYMPHOMAen
dc.subject.otherCHRONIC LYMPHOCYTIC-LEUKEMIAen
dc.subject.otherACUTE MYELOID-LEUKEMIAen
dc.subject.otherGENE-EXPRESSIONen
dc.subject.otherCLASS-IIen
dc.subject.otherTRANSCRIPTION FACTORen
dc.subject.otherTHERAPEUTIC TARGETSen
dc.subject.otherANTICANCER AGENTSen
dc.subject.otherINDUCE APOPTOSISen
dc.typeArtigo de periódicopt_BR
dc.type.categoryoriginal articlept_BR
dc.type.versionpublishedVersionpt_BR
dc.titleDifferential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemiapt_BR
dc.contributor.authorMORENO, Daniel Antunespt_BR
dc.contributor.authorSCRIDELI, Carlos Albertopt_BR
dc.contributor.authorCORTEZ, Maria Angelica Abdalapt_BR
dc.contributor.authorQUEIROZ, Rosane de Paulapt_BR
dc.contributor.authorVALERA, Elvis Tercipt_BR
dc.contributor.authorSILVEIRA, Vanessa da Silvapt_BR
dc.contributor.authorYUNES, Jose Andrespt_BR
dc.contributor.authorBRANDALISE, Silvia Reginapt_BR
dc.contributor.authorTONE, Luiz Gonzagapt_BR
unicamp.authorYUNES, Jose Andres:Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Pediatriapt_BR
unicamp.authorBRANDALISE, Silvia Regina:Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Pediatriapt_BR
unicamp.author.externalMORENO, Daniel Antunespt
unicamp.author.externalSCRIDELI, Carlos Albertopt
unicamp.author.externalQUEIROZ, Rosane de Paulapt
unicamp.author.externalVALERA, Elvis Tercipt
unicamp.author.externalSILVEIRA, Vanessa da Silvapt
unicamp.author.externalTONE, Luiz Gonzagapt
unicamp.author.externalCORTEZ, Maria Angelica Abdalapt
dc.subjectacute lymphoblastic leukaemiapt_BR
dc.subjectchildhoodpt_BR
dc.subjecthistone deacetylasept_BR
dc.subjectprognosispt_BR
dc.subjectgene expressionpt_BR
dc.subject.wosHematologypt_BR
dc.description.abstractAltered expression of histone deacetylases (HDACs) is a common feature in several human malignancies and may represent an interesting target for cancer treatment, including haematological malignancies. We evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative real-time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia (ALL) samples and its association with clinical/biological features and survival. ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples. HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL. Higher than median expression levels of HDAC3 were associated with a significantly lower 5-year event-free survival (EFS) in the overall group of patients (P = 0.03) and in T-ALL patients (P = 0.01). HDAC7 and HADC9 expression levels higher than median were associated with a lower 5-year EFS in the overall group (P = 0.04 and P = 0.003, respectively) and in B-lineage CD10-positive patients (P = 0.009 and P = 0.005, respectively). Our data suggest that higher expression of HDAC7 and HDAC9 is associated with poor prognosis in childhood ALL and could be promising therapeutic targets for the treatment of refractory childhood ALL.en
dc.relation.ispartofBritish Journal of Haematologypt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWILEY-BLACKWELL PUBLISHING, INCpt_BR
dc.date.issued2010pt_BR
dc.identifier.citationBRITISH JOURNAL OF HAEMATOLOGY, v.150, n.6, p.665-673, 2010pt_BR
dc.language.isoengpt_BR
dc.description.volume150pt_BR
dc.description.issuenumber6pt_BR
dc.description.initialpage665pt_BR
dc.description.lastpage673pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright WILEY-BLACKWELL PUBLISHING, INCpt_BR
dc.sourceWOSpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0007-1048pt_BR
dc.identifier.doi10.1111/j.1365-2141.2010.08301.xpt_BR
dc.identifier.urlhttp://dx.doi.org/10.1111/j.1365-2141.2010.08301.xpt_BR
dc.identifier.urlhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000281554500005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecordpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFAEPA (Brazil)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2013-07-26T17:58:25Z
dc.date.available2016-07-01T15:47:23Z-
dc.date.accessioned2013-07-26T17:58:25Z
dc.date.accessioned2016-07-01T15:47:23Z-
dc.description.provenanceMade available in DSpace on 2013-07-26T17:58:25Z (GMT). No. of bitstreams: 2 art_MORENO_Differential_expression_of_HDAC3_HDAC7_and_HDAC9_2010.pdf.txt: 50806 bytes, checksum: b4987e1223277b657d79d2863c218eb1 (MD5) art_MORENO_Differential_expression_of_HDAC3_HDAC7_and_HDAC9_2010.pdf: 161243 bytes, checksum: 0c761ac8433bcc741c148ea80cb73d81 (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2016-07-01T15:47:23Z (GMT). No. of bitstreams: 2 art_MORENO_Differential_expression_of_HDAC3_HDAC7_and_HDAC9_2010.pdf.txt: 50806 bytes, checksum: b4987e1223277b657d79d2863c218eb1 (MD5) art_MORENO_Differential_expression_of_HDAC3_HDAC7_and_HDAC9_2010.pdf: 161243 bytes, checksum: 0c761ac8433bcc741c148ea80cb73d81 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/735
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/735-
dc.contributor.departamentPediatria
dc.contributor.unidadeFCMpt
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