Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73498
Type: Artigo de periódico
Title: The influence of preparation conditions on the characteristics of chitosan-alginate dressings for skin lesions
Author: Rodrigues, AP
Sanchez, EMS
da Costa, AC
Moraes, AM
Abstract: In this work, the preparation and characterization of membranes obtained through chitosan and alginate coacervation and designed for use as wound dressings were evaluated. The influence of different stirring rates and rates of addition of chitosan solution to alginate solution on the final characteristics of the biomaterial was analyzed in detail, aiming at a simple and easily scalable membrane production protocol. The results show that membranes with dry thickness from 66 to 80 pm, wet thickness from 106 to 633 mu m, tensile strength varying from 6.86 to 31.14 MPa, elongation at break from 3.97 to 8.42%, and maximum water uptake up to 19 g of water per gram of membrane and that are able to prevent the permeation of bacteria can be obtained in a fairly reproducible way by the procedure established. The membranes prepared at flow ratio of 40 mL/h and stirring equal to 100 rpm showed a high potential for use on highly exuding wounds. (c) 2008 Wiley Periodicals, Inc.
Subject: membranes
biomaterials
polyelectrolytes
hydrogels
mechanical properties
chitosan
alginate
wound dressing
coacervates
Country: EUA
Editor: John Wiley & Sons Inc
Rights: fechado
Identifier DOI: 10.1002/app.28203
Date Issue: 2008
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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