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|Type:||Artigo de periódico|
|Title:||The influence of nicotine on the bone loss rate in ligature-induced periodontitis. A histometric study in rats|
|Abstract:||Background: The present study investigated the possible influence of nicotine on the bone loss rate in the furcation region due to ligature-induced periodontitis in rats. Methods: Twenty adult male Wistar rats were included. After anesthesia, the tooth was randomly assigned to receive the cotton ligature in the sulcular area, while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, including daily intraperitoneal injections: group A, 2 mul/g body weight of saline solution; group B, 2 mul/g body weight of a nicotine solution with 0.13 mul of nicotine/ml of saline solution; group C, 2 mul/g body weight of a nicotine solution with 0.19 mul of nicotine/ml of saline solution; and group D, 2 mul/g body weight of a nicotine solution with 0.26 mul of nicotine/ml of saline solution. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Results: Intergroup analysis revealed greater bone loss in the ligated teeth of group B (1.01 +/- 0.61 mm(2)), group C (1.14 +/- 0.72 mm(2)), and group D (1.36 +/- 0.60 mm(2)) when compared with group A (0.64 +/- 0.62 mm(2)) (P <0.01). However, no statistically significant differences in bone loss were found among groups B, C, and D. In addition, no bone loss was observed for unligated teeth (P >0.01). Conclusions: Within the limits of the present study, nicotine enhanced the effects of the local components of periodontal disease in a non-dose-dependent way; nevertheless, the administration of nicotine did not produce periodontal bone loss by itself.|
nicotine, adverse effects
|Editor:||Amer Acad Periodontology|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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