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Type: Artigo de periódico
Title: Variant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazil
Author: Da Silva, LHA
Spilki, FR
Riccetto, AGL
de Almeida, RS
Baracat, ECE
Arns, CW
Abstract: Background: Human metapneumovirus (HMPV) is a paramyxovirus associated with respiratory illness. The genotypes of HMPV isolates in Brazil have not been well characterized. Objectives: To investigate the presence of HMPV in clinical samples collected from pediatric patients of two university hospitals in the region of Campinas (Sao Paulo, Brazil) and to genotype them by partial sequencing of the HMPV F gene. Study design: Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI). Results: We identified HMPV in 8 of 142 (5.6%) clinical samples. We determined through phylogenetic analysis that HMPV isolates in Campinas during the study were clustered within subgroup B genotype 1. Two of the isolates analyzed showed significant differences from previously isolated B I viruses, when compared to HMPV isolated in South Africa and,Canada, and clustered in a separate branch within this genotype. Conclusions: In 2004 in our geographic region all HMPV isolates from pediatric patients were in the B I HMPV genetic group, with two variant isolates. (c) 2007 Elsevier B.V. All rights reserved.
Subject: human metapneumovirus
molecular characterization
genotype B subgroup 1
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.jcv.2007.11.010
Date Issue: 2008
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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