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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleValue of Conventional Pap Smear, Liquid-Based Cytology, Visual Inspection and Human Papillomavirus Testing as Optional Screening Tools Among Latin American Women < 35 and >= 35 Years of Age: Experience from the Latin American Screening Studypt_BR
dc.contributor.authorSyrjanen, Kpt_BR
dc.contributor.authorDerchain, Spt_BR
dc.contributor.authorRoteli-Martins, Cpt_BR
dc.contributor.authorLongatto, Apt_BR
dc.contributor.authorHammes, LSpt_BR
dc.contributor.authorSarian, Lpt_BR
unicamp.author.emailkari.syrjanen@tyks.fipt_BR
unicamp.authorSyrjaenen, Kari Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20521 Turku, Finland Univ Turku, Inst Dent, Dept Oral Pathol, Turku, Finland Hosp Clin Porto Alegre, Dept Gynecol & Obstet, Porto Alegre, RS, Brazil Univ Estadual Campinas, Dept Gynecol & Obstet, Hosp Leonor M de Barros, Sao Paulo, Brazil Inst Adolfo Lutz Registro, Sao Paulo, Brazil Digene Brazil, Sao Paulo, Brazil Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst, Braga, Portugal Hosp Clin Buenos Aires, Dept Gynecol, Buenos Aires, DF, Argentina Natl Inst Hlth, Unit Cytopathol, Natl Ctr Epidemiol Surveillance & Promot Hlth, Rome, Italy St Orsola Marcello Malpighi Hosp, Dept Obstet & Gynecol, Bologna, Italy SIZE Diagnost Ctr, Ljubljana, Slovenia Digene Corp, Gaithersburg, MD USApt_BR
dc.subjectcervical cancerpt_BR
dc.subjecthuman papillomaviruspt_BR
dc.subjectliquid-based cytologypt_BR
dc.subjectPapanicolaou smearpt_BR
dc.subjectverification biaspt_BR
dc.subject.wosLow-resource Settingspt_BR
dc.subject.wosRandomized Controlled-trialpt_BR
dc.subject.wosGrade Cervical Lesionspt_BR
dc.subject.wosRural Indiapt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosAccuracypt_BR
dc.subject.wosAdjunctpt_BR
dc.subject.wosRiskpt_BR
dc.subject.wosAbnormalitiespt_BR
dc.subject.wosMetaanalysispt_BR
dc.description.abstractObjective To compare performance of conventional Pap test, liquid-based cytology (LBC) and visual inspection. with acetic acid (VLA), as well as human papillomavirus (HPP) testing in, 2 subcohorts of women, <35 and >= 35 years of age. Study Design Performance indicators were calculated using colposcopic biopsies as the gold standard; all results were corrected for verification bias using maximum likelihood. Results Both conventional Pap test and Hybrid Capture 2 (HC2) assay Performed significantly better among older women than younger; no difference was observed in performance of LBC and VIA, both infierior to Pap and HC2. The Pap test was more specific than HC2 in both subcohorts; HC2 had the highest sensitivity. For individual tests, the best balance between sensitivity and specificity was obtained for HC2 assay corrected for verification bias in the older women's subcohort; this was further improved by the combined use of the Pap test and HC2. Conclusion Age of the target population is an important determinant of the performance of different screening tests. The choice of optimal test for women < 35 and >= 35 years of age depends on whether the highest positive predictive value (Pap test) Conclusion Age of the target population is an important determinant of the performance of different screening tests. The choice of optimal test for women < 35 and >= 35 years of age depends on whether the highest positive predictive value (Pap test) or the best SE/SP balance (HC2) is used as the selection criterion. (Acta Cytol 2008;52:641-653)pt
dc.relation.ispartofActa Cytologicapt_BR
dc.relation.ispartofabbreviationActa Cytol.pt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherKargerpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationNOV-DECpt_BR
dc.identifier.citationActa Cytologica. Karger, v. 52, n. 6, n. 641, n. 653, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume52pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage641pt_BR
dc.description.lastpage653pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.karger.com/Services/RightsPermissionspt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0001-5547pt_BR
dc.identifier.wosidWOS:000260986400001pt_BR
dc.identifier.doi10.1159/000325616pt_BR
dc.date.available2014-11-20T04:25:29Z
dc.date.available2015-11-26T17:14:07Z-
dc.date.accessioned2014-11-20T04:25:29Z
dc.date.accessioned2015-11-26T17:14:07Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:14:07Z (GMT). No. of bitstreams: 2 WOS000260986400001.pdf: 485717 bytes, checksum: 7c63f1082b5b7b350a0442d331954da5 (MD5) WOS000260986400001.pdf.txt: 61300 bytes, checksum: 7de0de8b935e86c7549d5edb445816e2 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73157pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/73157
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73157-
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