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Type: Artigo de periódico
Title: Validation of models of multivariate calibration: An application in the determination of polymorphic purity of carbamazepine by near infrared spectroscopy.
Author: Braga, JWB
Poppi, RJ
Abstract: The application of analytical procedures based on multivariate calibration models has been limited in several areas due to requirements of validation and certification of the model. Procedures for validation are presented based on the determination of figures of merit, such as precision (mean, repeatability, intermediate), accuracy, sensitivity, analytical sensitivity, selectivity, signal-to-noise ratio and confidence intervals for PLS models. An example is discussed of a model for polymorphic purity control of carbamazepine by NIR diffuse reflectance spectroscopy. The results show that multivariate calibration models can be validated to fulfill the requirements imposed by industry and standardization agencies.
Subject: validation
multivariate calibration
Country: Brasil
Editor: Soc Brasileira Quimica
Citation: Quimica Nova. Soc Brasileira Quimica, v. 27, n. 6, n. 1004, n. 1011, 2004.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422004000600027
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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