Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73036
Type: Artigo de periódico
Title: USE OF Y-CHROMOSOME-SPECIFIC DNA PROBES TO EVALUATE AN XX MALE
Author: FARAH, SB
GARMES, HM
CAVALCANTI, DP
MELLO, MP
PORRELLI, RN
RAMOS, CF
SARTORATO, EL
Abstract: 1. The function of a Y human chromosomal DNA sequence was evaluated. The Y-5 probe was isolated from a flow-sorted chromosome library and detects Y-specific sequences. 2. The Y-5 probe and other Y-specific probes were used to analyze an XX male patient without ambiguous genitalia. 3. DNA sequences from the short arm of the chromosome Y that were detected with pDP1007 and pDP105 in the patient's genome explain the testis differentiation observed in this case. 4. Failure of the patient's DNA to hybridize to the Y-5 probe shows that the primitive gonads can differentiate into testes even in the absence of this chromosome region. In contrast, a gene controlling spermatogenesis may exist in this region because the patient is azoospermic.
Subject: Y-CHROMOSOME-SPECIFIC DNA PROBES
SEX DETERMINATION
XX MALE
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Rights: aberto
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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