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Type: Artigo de periódico
Title: Venturi Easy Ambient Sonic-Spray Ionization
Author: Santos, VG
Regiani, T
Dias, FFG
Romao, W
Jara, JLP
Klitzke, CF
Coelho, F
Eberlins, MN
Abstract: The development and illustrative applications of an ambient ionization technique termed Venturi easy ambient sonic-spray ionization (V-EASI) is described. Its dual mode of operation with Venturi self-pumping makes V-EASI applicable to the direct mass spectrometric analysis of both liquid (V(L)-EASI) and solid (V(S)-EASI) samples. V-EASI is simple and easy to assemble, operating solely via the assistance of a sonic stream of nitrogen or air. The sonic gas stream causes two beneficial and integrated effects: (a) the self-pumping of solutions via the Venturi effect and (b) sonic-spray ionization (SSI) of analytes either in solution or resting on solid surfaces. In its liquid mode, V(L)-EASI is applicable to analytes in solution, forming negatively and/or positively charged intact molecular species in a soft fashion with little or no fragmentation. In its solid mode, V(S)-EASI relies on Venturi self-pumping of a proper SSI solvent solution in combination with SSI to form a stream of bipolar charged droplets that bombard the sample surface, causing desorption and ionization of the analyte molecules. As for its precursor technique (EASI), V-EASI generates bipolar droplets with considerably lower average charging, which increases selectivity for ionization with high signal-to-noise ratios and clean spectra dominated by single molecular species with minimal solvent ions. V-EASI also operates in a voltage-, heat-, and radiation-free fashion and is therefore free of thermal, electrical, or discharge interferences.
Country: EUA
Editor: Amer Chemical Soc
Citation: Analytical Chemistry. Amer Chemical Soc, v. 83, n. 4, n. 1375, n. 1380, 2011.
Rights: fechado
Identifier DOI: 10.1021/ac102765z
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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