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Type: Artigo de periódico
Title: The Use of PLDLA/PCL-T Scaffold to Repair Osteochondral Defects in vivo
Author: Esposito, AR
Bonadio, AC
Pereira, NO
Cardoso, TP
Barbo, MLP
Duek, EAD
Abstract: The physiological repair of osteochondral lesions requires the development of a scaffold that is compatible with the structure of the damaged tissue, cartilage and bone. The aim of this study was to evaluate the biological performance of a PLDLA/PCL-T (90/10) scaffold for repairing osteochondral defects in rabbits. Polymeric scaffolds containing saccharose (75% w/v) were obtained by solvent casting and then implanted in the medial knee condyles of 12 New Zealand rabbits after osteochondral damage with a trephine metallic drill (diameter: 3.3 mm) in both medial femoral condyles. Each rabbit received the same treatment, i.e., the polymeric scaffold was implanted on the right side while no material was implanted on the left side (control). Four and 12 weeks later histological examination revealed bone neoformation in the implant group, with the presence of hyaline cartilage and mesenchymal tissue. In contrast, the control group showed bone neoformation with necrosis, exacerbated superficial fibrosis, inflammation and cracks in the neoformed tissue. These findings indicate that the PLDLA/PCL-T scaffold was biocompatible and protected the condyles by stabilizing the lesion and allowing subchondral bone tissue and hyaline cartilage formation.
Subject: biomaterials
osteochondral repair
Country: Brasil
Editor: Univ Fed Sao Carlos, Dept Engenharia Materials
Rights: aberto
Identifier DOI: 10.1590/S1516-14392012005000155
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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