Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: eNOS haplotypes associated with gestational hypertension or preeclampsia
Author: SANDRINI, Valeria C.
PALEI, Ana C. T.
CAVALLI, Ricardo C.
ARAUJO, Francielle M.
RAMOS, Ester S.
DUARTE, Geraldo
Abstract: Aims: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia. We compared genotype and haplotype frequencies of three eNOS gene polymorphisms in normotensive and hypertensive pregnancies. Methods: Genotypes and haplotypes for eNOS polymorphisms (T-786C, Glu298Asp and intron 4 b/a) were determined in 326 pregnant women (1110 healthy pregnancies, 103 gestational hypertensives and 113 preeclamptic). Results: No differences were observed in the frequencies of genotypes and alleles of the three polymorphisms among the groups (all p > 0.05). However, the haplotype `T Glu a` was more common in healthy pregnancies than in gestational hypertensives or preeclamptic (20 vs 6 and 6%, respectively; p < 0.0032). Conversely, the haplotype `C Glu a` was more common in gestational hypertensives and preeclamptic than in healthy pregnancies (117 vs 17 and 5%; p = 0.0061). Conclusion: These findings suggest a contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNOS genotypes alone are considered.
Subject: endothelial nitric oxide synthase
gestational hypertension
nitric oxide
Country: Inglaterra
Citation: PHARMACOGENOMICS, v.9, n.10, p.1467-1473, 2008
Rights: fechado
Identifier DOI: 10.2217/14622416.9.10.1467
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.