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Type: Artigo de periódico
Title: The Solid-State Cultivation of Streptococcus zooepidemicus in Polyurethane Foam as a Strategy for the Production of Hyaluronic Acid
Author: Ferrari, FA
Motta, FL
Bastos, RG
Santana, MHA
Abstract: Hyaluronic acid (HA) is a biopolymer with important applications in the pharmaceutical, medical, and cosmetic fields. This work explores the potentialities of a cylindrical polyurethane foam dowel with central aeration as a novel packed bed bioreactor for the production of HA. The goals were to provide a large surface area for oxygen transfer through the patches of liquid film that form in the pores of the foam in which cell proliferation and HA production occur and to easily recover the HA produced. The resulting yields of HA/cell were higher than 1, and the produced HA was completely recovered by pressing the foam. The external conditions that inhibit catabolism, the deviation of energetic metabolism toward the production of HA, were modulated by aeration and the initial glucose concentration. The production of HA was reproducible in 12 successive fermentation cycles. These findings contribute to the development of efficient strategies for the controlled production and recovery of HA.
Subject: Hyaluronic acid
Polyurethane foam
Streptococcus zooepidemicus
Solid-state cultivation
Country: EUA
Editor: Humana Press Inc
Citation: Applied Biochemistry And Biotechnology. Humana Press Inc, v. 170, n. 6, n. 1491, n. 1502, 2013.
Rights: fechado
Identifier DOI: 10.1007/s12010-013-0293-0
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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