Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/72430
Type: Artigo de periódico
Title: THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy
Author: Maurer-Morelli, CV
Secolin, R
Marchesini, RB
Santos, NF
Kobayashi, E
Cendes, F
Lopes-Cendes, I
Abstract: A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. (c) 2006 Elsevier B.V. All rights reserved.
Subject: candidate locus
genetics
microsatellites
linkage study
voltage-gated sodium channel
hippocampal sclerosis
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.eplepsyres.2006.06.016
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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