Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy
Author: Maurer-Morelli, CV
Secolin, R
Marchesini, RB
Santos, NF
Kobayashi, E
Cendes, F
Lopes-Cendes, I
Abstract: A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. (c) 2006 Elsevier B.V. All rights reserved.
Subject: candidate locus
linkage study
voltage-gated sodium channel
hippocampal sclerosis
Country: Holanda
Editor: Elsevier Science Bv
Citation: Epilepsy Research. Elsevier Science Bv, v. 71, n. 41700, n. 233, n. 236, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.eplepsyres.2006.06.016
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000241310300017.pdf113.22 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.