Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/72387
Type: Artigo de periódico
Title: The role of magnesium in the endothelial dysfunction caused by global ischemia followed by reperfusion: in vitro study of canine coronary arteries
Author: Volpe, MA
Carneiro, JJ
Magna, LA
Viaro, F
Origuela, EAL
Evora, PRB
Abstract: Objective-To study the role of magnesium in the endothelial dysfunction of canine coronary arteries caused by cardiopulmonary bypass (CPB) global ischemia followed by reperfusion. Design-Segments of canine coronary arteries were suspended in organ chambers to measure isometric contraction by prostaglandin F-2alpha, and relaxed by acetylcholine (ACh), sodium fluoride (NaF), calcium ionophore (A(23187)) and sodium nitroprusside (SNP) in crescent concentrations. The investigation protocol had groups with six dogs: CONTROL group (without CPB), CPB group (105 min of CPB without aortic cross-clamping), ISCH group (45 min of CPB with aortic cross-clamping), ISCH/REP group (45 min of aortic cross-clamping followed by 60 min of reperfusion). The coronary relaxations were evaluated with (phase I), without (phase II) and restored magnesium (phase III) to the organ bath. Results-The presence of magnesium in the organ bath was associated with the greater relaxation in response to agonists of the nitric oxide production. The removal of magnesium from the organ bath was associated with the reduction in the intensity of vessel relaxation. The magnesium restoration to the organ bath was associated with the additional reduction in the intensity of relaxation with the exception of NaF that allowed reacquisition of the relaxation observed in the presence of magnesium. Conclusion-This in vitro study demonstrates that magnesium ion favorably influences the nitric oxide production by the coronary endothelium, attenuating the endothelial dysfunction caused by global ischemia followed by reperfusion.
Subject: coronary reperfusion
endothelium
G-proteins
ischemia
magnesium
nitric oxide
Country: Noruega
Editor: Taylor & Francis As
Rights: fechado
Identifier DOI: 10.1080/14017430310014939
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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