Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/72383
Type: Artigo de periódico
Title: The role of ion pairing in the chromatographic study of propranolol analogues
Author: Britto, MM
Cass, QB
Jardim, ICSF
Montanari, CA
Aboul-Enein, HY
Abstract: The partition coefficients, log P-app(RPLC), for a series of propranolol analogues have been determined by reversed phase high performance liquid chromatography. The hydrochloride salts and free base log P-app(RPLC) show that charged and uncharged species can partition into the reversed phase. An extrathermodynamic relationship was found for log P-app(RPLC) measured in two different column stationary phases, C8 and PMOS, suggesting that the same sei of compounds experience a similar trend in these elution systems. The importance of using phosphate and/or MOPS buffer is due to the fact that the latter can avoid ion-pairing partitioning, but the former does play the same role for PMOS column when the free base is considered.
Subject: column liquid chromatography
structure-retention relationships
propranolol analogues
Country: Alemanha
Editor: Vieweg
Rights: fechado
Identifier DOI: 10.1007/BF02492420
Date Issue: 2001
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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