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|Type:||Artigo de periódico|
|Title:||The role of ion pairing in the chromatographic study of propranolol analogues|
|Abstract:||The partition coefficients, log P-app(RPLC), for a series of propranolol analogues have been determined by reversed phase high performance liquid chromatography. The hydrochloride salts and free base log P-app(RPLC) show that charged and uncharged species can partition into the reversed phase. An extrathermodynamic relationship was found for log P-app(RPLC) measured in two different column stationary phases, C8 and PMOS, suggesting that the same sei of compounds experience a similar trend in these elution systems. The importance of using phosphate and/or MOPS buffer is due to the fact that the latter can avoid ion-pairing partitioning, but the former does play the same role for PMOS column when the free base is considered.|
|Subject:||column liquid chromatography|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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