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Type: Artigo de periódico
Title: The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions
Author: Giraldo, PC
Eleuterio, J
Cavalcante, DIM
Goncalves, AKS
Romao, JAA
Eleuterio, RMN
Abstract: Objectives: The objectives were to assess the prevalence of high-risk HPV in the male sexual partners of women with HPV-induced lesions, and correlate it with biopsies guided by peniscopy. Study design: Fifty-four asymptomatic male sexual partners of women with low-grade squamous intra-epithelial lesions (LSIL) associated with high-risk HPV were examined between April 2003 and June 2005. The DNA-HPVA,as tested using a second-generation hybrid capture technique in scraped penile samples. Peniscopy identified acetowhite lesions leading to biopsy. Results: High-risk HPV was present in 25.9% (14 out of 54) of the cases. Peniscopy led to 13 biopsies (24.07%), which resulted in two cases of condyloma, two cases of intra-epithelial neoplasia (PIN) I, one case of PIN II, and eight cases of normal tissue. The high-risk HPV test demonstrated 80% sensitivity, 100% specificity, 100% positive predictive value, and 88.9% negative predictive value for the identification of penile lesions. There was a greater chance of finding HPV lesions in the biopsy in the positive cases of high-risk HPV with abnormal peniscopy (p = 0.007); OR = 51 (CI 1.7-1527.1). Conclusion: Among asymptomatic male sexual partners of women with low-grade intra-epithelial squamous lesions, those infected by high-risk HPV have a higher chance of having abnormal penile tissue compared with male partners without that infection. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Subject: human papillomavirus
hybrid capture
STD in males
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: European Journal Of Obstetrics Gynecology And Reproductive Biology. Elsevier Ireland Ltd, v. 137, n. 1, n. 88, n. 91, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.ejogrb.2006.12.026
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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