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|Type:||Artigo de periódico|
|Title:||The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis|
|Abstract:||PURPOSE: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-beta, IRS-1, IRS-2, IGF-IR beta and Ikappa beta in experimental model of gastroschisis. METHODS: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW. IR-beta and IGF-IR beta receptors, IRS-1 and IRS-2 substrates and Ikappa beta protein were analyzed by western blotting. RESULTS: BW was lower in G, the IW and IW / BW were greater than C and S (p<0.05) groups. The liver showed no differences between groups. In fetuses with gastroschisis, compared with control fetuses, the expression of IGF-IR beta (p<0.001) and Ikappa beta (p<0.001) increased in the liver and intestine, as well as IR-beta (p<0.001) which decreased in both. In contrast to the intestine, IRS-1 (p<0.001) increased in the liver and IRS-2 decreased (p<0.01). CONCLUSION: The axis of the intestine liver has an important role in inflammation, with consequent changes in the metabolic pathway of glucose can contribute to the IUGR in fetuses with gastroschisis.|
Fetal Growth Retardation
|Editor:||Acta Cirurgica Brasileira|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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