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Type: Artigo de periódico
Title: The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis
Author: Bueno, MP
Goncalves, FLL
Guadagnini, D
Barini, R
Saad, MJA
Gallindo, RM
Schmidt, AF
Sbragia, L
Abstract: PURPOSE: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-beta, IRS-1, IRS-2, IGF-IR beta and Ikappa beta in experimental model of gastroschisis. METHODS: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW. IR-beta and IGF-IR beta receptors, IRS-1 and IRS-2 substrates and Ikappa beta protein were analyzed by western blotting. RESULTS: BW was lower in G, the IW and IW / BW were greater than C and S (p<0.05) groups. The liver showed no differences between groups. In fetuses with gastroschisis, compared with control fetuses, the expression of IGF-IR beta (p<0.001) and Ikappa beta (p<0.001) increased in the liver and intestine, as well as IR-beta (p<0.001) which decreased in both. In contrast to the intestine, IRS-1 (p<0.001) increased in the liver and IRS-2 decreased (p<0.01). CONCLUSION: The axis of the intestine liver has an important role in inflammation, with consequent changes in the metabolic pathway of glucose can contribute to the IUGR in fetuses with gastroschisis.
Subject: Gastroschisis
Fetal Growth Retardation
Receptor, Insulin
Fetal Development
Country: Brasil
Editor: Acta Cirurgica Brasileira
Rights: aberto
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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