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Type: Artigo de periódico
Title: The Relationship between Apelin and Parathyroid Hormone in Hemodialysis Patients
Author: Mafra, D
Lobo, JC
Farage, NE
Stockler-Pinto, MB
Leal, VO
Calixto, A
Geloneze, B
Abstract: Both apelin and parathyroid hormone (PTH) are endogenous ligands for G-protein-coupled receptors. Apelin acts as a mitogenic agent for osteoblasts, and metabolic bone abnormalities are frequently seen in hemodialysis (HD) patients because of hyperparathyroidism. The aim of this study was to analyze plasma apelin levels in HD patients and to determine whether they are related to PTH concentrations. A total of 23 HD patients [15 men and 8 women, with a mean (SD) age of 54.2 (4.4) years and a mean body mass index (BMI) of 25.0 (4.1) kg/m(2)] were studied and compared with 15 healthy subjects [6 men and 9 women, with a mean (SD) age of 51.3 (13.6) years and a BMI of 27.0 (4.3) kg/m(2)]. Plasma apelin-36 was measured using an enzyme immunometric assay method and PTH was measured by ELISA. There was no significant difference in apelin levels between the patients [0.80 (0.6) ng/mL] and the healthy subjects [0.83 (0.23) ng/mL]. There was a positive correlation between apelin and PTH (r = 0.66, p = 0.0001). The patients with PTH >300 pg/mL had significantly higher plasma apelin levels [1.17 (0.7) ng/mL] compared with the patients with PTH <300 pg/mL [0.50 (0.15) ng/mL] (p = 0.003). In conclusion, HD patients with secondary hyperparathyroidism have high plasma apelin levels, which suggest that apelin may protect bone in HD patients by acting as an osteoblastic factor.
Subject: apelin
parathyroid hormone
bone mineral density
chronic kidney disease
Country: Inglaterra
Editor: Informa Healthcare
Citation: Renal Failure. Informa Healthcare, v. 34, n. 8, n. 970, n. 973, 2012.
Rights: fechado
Identifier DOI: 10.3109/0886022X.2012.700675
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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