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Type: Artigo de periódico
Title: The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor
Author: Sousa, NC
Anicchino-Bizzacchi, JM
Locatelli, MF
Castro, V
Barjas-Castro, ML
Abstract: The aim of this study was to correlate ABO groups with plasma levels of factor Vill (FV111), von Willebrand factor (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological and molecular tests defined blood groups from 114 donors (10 AA, 10 BB, 10 AB, 10 A0(1), 10 B0(1), 16 0(1)0(1), 20A(2)0(1), 20 A(2)B, 4 A(3)0(1), 3A(x)0(1), and 1 B(el)0(1)). The levels of VWF:Ag, FV111 and VWF:RCo observed in rare subgroups (A(3)0(1), A(x)0(1), B(el)0(1)) were similar to the values found in the 0101 group. However, levels of these factors were significantly higher in A(2)0(1) donors than in 0(1)0(1) donors (VWF:Ag p=0.01; FV111 p=0.04; VWF:RCo p < 0.001). Strong correlations were demonstrated between plasma levels of VWF:Ag and FV111 (R=0.77; p=0.001) and between VWF:Ag and VWF:RCo (R=0.75; P=0.001).
Subject: ABO
blood groups
factor VIII
von Willbrand factor
Country: Itália
Editor: Ferrata Storti Foundation
Rights: fechado
Identifier DOI: 10.3324/haematol.10457
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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