Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/723
Type: Artigo de periódico
Title: Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension
Author: MONTENEGRO, Marcelo F.
AMARAL, Jefferson H.
PINHEIRO, Lucas C.
SAKAMOTO, Eliana K.
FERREIRA, Graziele C.
REIS, Rosana Inacio
MARCAL, Diogo M. O.
PEREIRA, Romaiana P.
TANUS-SANTOS, Jose E.
Abstract: Dietary nitrite and nitrate are important sources of nitric oxide (NO). However, the use of nitrite as an antihypertensive drug may be limited by increased oxidative stress associated with hypertension. We evaluated the antihypertensive effects of sodium nitrite given in drinking water for 4 weeks in two-kidney one-clip (21(1 C) hypertensive rats and the effects induced by nitrite on NO bioavailability and oxidative stress. We found that, even under the increased oxidative stress conditions present in 2K1C hypertension, nitrite reduced systolic blood pressure in a dose-dependent manner. Whereas treatment with nitrite did not significantly change plasma nitrite concentrations in 2K1C rats, it increased plasma nitrate levels significantly. Surprisingly, nitrite treatment exerted antioxidant effects in both hypertensive and sham-normotensive control rats. A series of in vitro experiments was carried out to show that the antioxidant effects induced by nitrite do not involve direct antioxidant effects or xanthine oxidase activity inhibition. Conversely, nitrite decreased vascular NADPH oxidase activity. Taken together, our results show for the first time that nitrite has antihypertensive effects in 2K1C hypertensive rats, which may be due to its antioxidant properties resulting from vascular NADPH oxidase activity inhibition. (C) 2011 Elsevier Inc. All rights reserved.
Subject: Nitrite
Antioxidants
NADPH oxidase
Nitric oxide
Xanthine oxidase
2K1C hypertension
Free radicals
Country: Estados Unidos
Editor: ELSEVIER SCIENCE INC
Rights: fechado
Identifier DOI: 10.1016/j.freeradbiomed.2011.04.005
Address: http://dx.doi.org/10.1016/j.freeradbiomed.2011.04.005
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Date Issue: 2011
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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