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Type: Artigo de periódico
Title: Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice
Author: Asakura, L
Cazita, PM
Harada, LM
Nunes, VS
Berti, JA
Salerno, AG
Ketelhuth, DFJ
Gidlund, M
Oliveira, HCF
Quintao, ECR
Abstract: The possibility that soy protein containing isoflavones influences the development of experimental atherosclerosis has been investigated in ovariectomized mice heterozygous for the human CETP transgene and for the LDL-receptor null allele (LDLr+/- CETP+/-). After ovariectomy at 8 wk of age they were fed a fat/cholesterol-rich diet for 19 wk and divided into three experimental groups: dietary unmodified soy protein containing isoflavones (mg/g of diet), either at low-dose (Iso Low, 0.272, n = 25), or at high-dose (Iso High, 0.535, n = 28); and the atherogenic diet containing an isoflavone-depleted alcohol-washed soy protein as a control group (n = 28). Aortic root lipid-stained lesion area (mean mu m(2) X 10(3) +/- SD) did not differ among]so Low (12.3 +/- 9.9),]so High (7.4 +/- 6.4), and controls (10.7 +/- 12.8). Autoantibody titers against plasma oxidized LDL did not differ among the experimental groups. Using the control mice as the reference value (100%), in vitro mouse peritoneal macrophage uptake of labeled acetylated LDL-cholesterol was lower in the Iso High (68%) than in the Iso Low (85%) group. The in vitro percent removal by exogenous HDL of labeled unesterified cholesterol from macrophages previously enriched with human [4-C-14]-cholesteryl oleate acetylated LDL was enhanced in the Iso High group (50%). In spite of these in vitro potentially antiatherogenic actions, soy protein containing isoflavones did not modify the average size of lipid-stained area in the aortic root.
Country: EUA
Editor: Amer Oil Chemists Soc A O C S Press
Rights: fechado
Identifier DOI: 10.1007/s11745-006-5016-7
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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