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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSodium butyrate does not decrease the evolution of precancerous lesions in ratspt_BR
dc.contributor.authorSilva, FGDEpt_BR
dc.contributor.authorPenido, LCPpt_BR
dc.contributor.authorValente, FXpt_BR
dc.contributor.authorMendes, MCSpt_BR
dc.contributor.authorRosa, DDpt_BR
dc.contributor.authorGloria, MBApt_BR
dc.contributor.authorPeluzio, MDGpt_BR
unicamp.authorRosa, Damiana Diniz Gouveia Peluzio, Maria do Carmo Univ Fed Vicosa, Dept Nutr & Saude, BR-36570000 Vicosa, MG, Brazilpt_BR
unicamp.authorDrummond e Silva, Fernanda Guimaraes Penna Penido, Luisa Costa Valente, Flavia Xavier Univ Fed Vicosa, Sci Initiat Program, BR-36570000 Vicosa, MG, Brazilpt_BR
unicamp.authorSantos Mendes, Maria Carolina Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Campinas, SP, Brazilpt_BR
unicamp.authorAbreu Gloria, Maria Beatriz Univ Fed Minas Gerais, Sch Pharm, Dept Food, Belo Horizonte, MG, Brazilpt_BR
dc.subjectColonic Neoplasmspt_BR
dc.subjectPrecancerous Conditionspt_BR
dc.subject.wosAberrant Crypt Focipt_BR
dc.subject.wosResistant Starchpt_BR
dc.description.abstractPurpose: To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH). Methods: Forty Wistar rats were separated into four groups (n=10) distributed as follows: control 1, control 2, butyrate 1 and butyrate 2. The groups control 1 and butyrate 1 remained under experimentation for 4 weeks, while the groups control 2 and butyrate 2 remained for 8 weeks. In the first four weeks, the animals of the control groups received water ad libitum and the animals of the butyrate groups received a sodium butyrate solution (3.4%) ad libitum. Injections of the drug 1,2-dimethylhydrazine were applied during the two first weeks of the experiment in all the animals, concurrently with the application of sodium butyrate. The large intestine of the animals was removed, for the analysis of the ACF and of the content of polyamines. The animal feces were collected for the analysis of the SCFA profile. Results: The spermidine presented a higher concentration in the group butyrate 2 in comparison to the group control 2. There was a significant difference in the concentration value (mu mol/mL) of acetate in comparison to the groups control 2 and butyrate 2. Conclusion: The use of sodium butyrate together with the induction of colorectal cancer was not effective in the prevention of the disease
dc.relation.ispartofActa Cirurgica Brasileirapt_BR
dc.relation.ispartofabbreviationActa Cir. Bras.pt_BR
dc.publisher.citySao Paulopt_BR
dc.publisherActa Cirurgica Brasileirapt_BR
dc.identifier.citationActa Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 25, n. 6, n. 507, n. 512, 2010.pt_BR
dc.sourceWeb of Sciencept_BR
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