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Type: Artigo de periódico
Title: mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor
Author: SCRIDELI, Carlos Alberto
CORTEZ, Maria Angelica Abdala
YUNES, Jose Andres
QUEIROZ, Rosane Gomes de Paula
VALERA, Elvis Terci
MATA, Juliana Franca da
TELEDO, Silvia Regina Caminada
LEE, Maria Lucia de Martino
PETRILLI, Antonio Sergio
BRANDALISE, Silvia Regina
TONE, Luiz Gonzaga
Abstract: This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL. (c) 2009 Elsevier Ltd. All rights reserved.
Subject: Inibidores teciduais de metaloproteinases
Country: Inglaterra
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.leukres.2009.10.007
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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