Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/717
Type: Artigo de periódico
Title: mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor
Author: SCRIDELI, Carlos Alberto
CORTEZ, Maria Angelica Abdala
YUNES, Jose Andres
QUEIROZ, Rosane Gomes de Paula
VALERA, Elvis Terci
MATA, Juliana Franca da
TELEDO, Silvia Regina Caminada
PAVONI-FERREIRA, Priscila
LEE, Maria Lucia de Martino
PETRILLI, Antonio Sergio
BRANDALISE, Silvia Regina
TONE, Luiz Gonzaga
Abstract: This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL. (c) 2009 Elsevier Ltd. All rights reserved.
Subject: Childhood ALL
MMP
TIMP
Prognostic factor
Country: Inglaterra
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Citation: LEUKEMIA RESEARCH, v.34, n.1, p.32-37, 2010
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2009.10.007
Address: http://dx.doi.org/10.1016/j.leukres.2009.10.007
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000274528800005&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2010
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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