Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/71654
Type: Artigo de periódico
Title: SARCOPLASMIC-ENDOPLASMIC-RETICULUM CA(2+)-ATPASE AND CALSEQUESTRIN ARE OVEREXPRESSED IN SPARED INTRINSIC LARYNGEAL MUSCLES OF DYSTROPHIN-DEFICIENT MDX MICE
Author: Ferretti, R
Marques, MJ
Pertille, A
Neto, HS
Abstract: In the mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILM) are protected and do not undergo myonecrosis. We investigated whether this protection is related to an increased expression of calcium-binding proteins, which may protect against the elevated calcium levels seen in dystrophic fibers. The expression of sarcoplasmic-endoplasmic-reticulum Ca(2+)-ATPase and calsequestrin was examined in ILM and in nonspared limb muscles of control and mdx mice using immunofluorescence and immunoblotting. Dystrophic ILM presented a significant increase in the proteins studied when compared to controls. The increase of Ca(2+)-handling proteins in dystrophic ILM may permit better maintenance of calcium homeostasis, with the consequent absence of myonecrosis. The results further support the concept that abnormal Ca(2+)-handling is involved in dystrophinopathies.
Subject: calsequestrin
Duchenne Muscular dystrophy
intrinsic laryngeal muscles
mdx mice
SERCA1
Country: EUA
Editor: John Wiley & Sons Inc
Rights: fechado
Identifier DOI: 10.1002/mus.21154
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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