Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/71652
Type: Artigo de periódico
Title: SAR ANALYSIS OF SYNTHETIC NEOLIGNANS AND RELATED-COMPOUNDS WHICH ARE ANTI-LEISHMANIASIS ACTIVE COMPOUNDS USING PATTERN-RECOGNITION METHODS
Author: COSTA, MCA
BARATA, LES
TAKAHATA, Y
Abstract: Potentially active new neolignan and analogues against leishmaniasis are proposed. Structure-activity relationship (SAR) techniques were employed. Physicochemical properties such as log P, molecular volume, atomic charge and quantum chemical parameters were calculated for a group of synthetic substances for which the biological activities against leishmaniasis are known. Only about half a dozen out of more than twenty parameters were found to be efficient for the classification of the compounds into active and inactive groups.
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Date Issue: 1995
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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