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|Type:||Artigo de periódico|
|Title:||SAR ANALYSIS OF SYNTHETIC NEOLIGNANS AND RELATED-COMPOUNDS WHICH ARE ANTI-LEISHMANIASIS ACTIVE COMPOUNDS USING PATTERN-RECOGNITION METHODS|
|Abstract:||Potentially active new neolignan and analogues against leishmaniasis are proposed. Structure-activity relationship (SAR) techniques were employed. Physicochemical properties such as log P, molecular volume, atomic charge and quantum chemical parameters were calculated for a group of synthetic substances for which the biological activities against leishmaniasis are known. Only about half a dozen out of more than twenty parameters were found to be efficient for the classification of the compounds into active and inactive groups.|
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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