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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleScreening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocainept_BR
dc.contributor.authorMoraes, CMpt_BR
dc.contributor.authorde Matos, APpt_BR
dc.contributor.authorGrillo, Rpt_BR
dc.contributor.authorde Melo, NFSpt_BR
dc.contributor.authorde Paula, Ept_BR
dc.contributor.authorDias, NLpt_BR
dc.contributor.authorRosa, AHpt_BR
dc.contributor.authorFraceto, LFpt_BR
unicamp.authorMoraes, Carolina Morales de Matos, Angelica Prado de Melo, Nathalie F. S. de Paula, Eneida Fraceto, Leonardo Fernandes State Univ Campinas UNICAMP, Dept Biochem, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorGrillo, Renato de Melo, Nathalie F. S. Rosa, Andre Henrique Fraceto, Leonardo Fernandes Unesp Univ Estadual Paulista, Dept Environm Engn, BR-18087180 Sao Paulo, Brazilpt_BR
unicamp.authorDias Filho, Newton Luiz Unesp Univ Estadual Paulista, Dept Phys & Chem, BR-15385000 Sao Paulo, Brazilpt_BR
dc.subjectExperimental Designpt_BR
dc.subject2(4-1) Factorial Experimentalpt_BR
dc.subjectNanoparticlespt_BR
dc.subjectPolymeric Nanocapsulespt_BR
dc.subjectLocal Anestheticpt_BR
dc.subject.wosFactorial Designpt_BR
dc.subject.wosPlga Nanoparticlespt_BR
dc.subject.wosPhysicochemical Characterizationpt_BR
dc.subject.wosSpontaneous Emulsificationpt_BR
dc.subject.wosDrug Incorporationpt_BR
dc.subject.wosOptimizationpt_BR
dc.subject.wosDiffusionpt_BR
dc.subject.wosSolventpt_BR
dc.subject.wosNanospherespt_BR
dc.subject.wosStabilitypt_BR
dc.description.abstractIn this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations.pt
dc.relation.ispartofJournal Of Nanoscience And Nanotechnologypt_BR
dc.relation.ispartofabbreviationJ. Nanosci. Nanotechnol.pt_BR
dc.publisher.cityStevenson Ranchpt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Scientific Publisherspt_BR
dc.date.issued2011pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationJournal Of Nanoscience And Nanotechnology. Amer Scientific Publishers, v. 11, n. 3, n. 2450, n. 2457, 2011.pt_BR
dc.language.isoenpt_BR
dc.description.volume11pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage2450pt_BR
dc.description.lastpage2457pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn1533-4880pt_BR
dc.identifier.wosidWOS:000288102300090pt_BR
dc.identifier.doi10.1166/jnn.2011.3547pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [06-00121-9, 07/00127-0]pt
dc.date.available2014-07-30T18:35:44Z
dc.date.available2015-11-26T16:35:57Z-
dc.date.accessioned2014-07-30T18:35:44Z
dc.date.accessioned2015-11-26T16:35:57Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T18:35:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:35:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71556
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71556-
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