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Type: Artigo de periódico
Title: Screening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine
Author: Moraes, CM
de Matos, AP
Grillo, R
de Melo, NFS
de Paula, E
Dias, NL
Rosa, AH
Fraceto, LF
Abstract: In this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations.
Subject: Experimental Design
2(4-1) Factorial Experimental
Polymeric Nanocapsules
Local Anesthetic
Country: EUA
Editor: Amer Scientific Publishers
Citation: Journal Of Nanoscience And Nanotechnology. Amer Scientific Publishers, v. 11, n. 3, n. 2450, n. 2457, 2011.
Rights: fechado
Identifier DOI: 10.1166/jnn.2011.3547
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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