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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSensitivity to beta-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benthpt_BR
dc.contributor.authorGrassi-Kassisse, DMpt_BR
dc.contributor.authorWolf-Nunes, Vpt_BR
dc.contributor.authorMiotto, AMpt_BR
dc.contributor.authorFarias-Silva, Ept_BR
dc.contributor.authorBrito, ARMSpt_BR
dc.contributor.authorNunes, DSpt_BR
dc.contributor.authorSpadari-Bratfisch, RCpt_BR
unicamp.authorUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, UNICAMP, BR-13083970 Campinas, SP, Brazil Univ Estadual Ponta Grossa, Inst Quim, BR-84035310 Ponta Grossa, PR, Brazilpt_BR
dc.subject.wosFat-cell Functionpt_BR
dc.subject.wosWhite Adipocytespt_BR
dc.subject.wosEssential Oilpt_BR
dc.description.abstractAqueous extracts of Croton cajucara bark are used in folk medicine to treat hepatic and gastrointestinal disorders and as a coadjuvant in weight-loss programs. We examined the effect of treating rats for 15 days with a 5% aqueous extract of C. cajucara on body weight and food intake. The epididymal adipose pads were removed and the lipolytic responses of isolated adipocytes to isoprenaline, noradrenaline (norepinephrine), BRL37344 and adrenaline (epinephrine) were analysed in the absence or presence of metoprolol or ICI118,551. Treated rats had a significantly lower weight gain than control rats, with no difference in food and liquid intake, epididymal fat-pad weight or basal glycerol release. The sensitivity of the lipolytic response to isoprenaline and adrenaline was significantly higher in adipocytes from treated rats. The sensitivity to noradrenaline or BRL37344 was unaltered. Metoprolol shifted the dose-response curves to noradrenaline to the right in adipocytes from control and treated rats; the dose-response curve to isoprenaline in adipocytes from control rats was also shifted to the right. In adipocytes from treated rats, the dose-response curve to isoprenaline was unaltered by metoprolol but was shifted to the right by ICI118,551, a beta(2)-adrenoceptor antagonist. We conclude that in adipocytes from treated rats there is an increase in the lipolytic response to non-selective agonists (isoprenaline and adrenaline) mediated by beta(2)-adrenoceptors, with no alteration in the responses mediated by beta(1)-adrenoceptors (noradrenaline) or beta(3)-adrenoceptors (BRL37344). This effect could increase the role of adrenaline as an endogenous stimulator of
dc.relation.ispartofJournal Of Pharmacy And Pharmacologypt_BR
dc.relation.ispartofabbreviationJ. Pharm. Pharmacol.pt_BR
dc.publisherRoyal Pharmaceutical Soc Great Britainpt_BR
dc.identifier.citationJournal Of Pharmacy And Pharmacology. Royal Pharmaceutical Soc Great Britain, v. 55, n. 2, n. 253, n. 257, 2003.pt_BR
dc.sourceWeb of Sciencept_BR
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