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Type: Artigo de periódico
Title: Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS Study
Author: Longatto, A
Roteli-Martins, C
Hammes, L
Etlinger, D
Pereira, SMM
Erzen, M
Branca, M
Naud, P
Derchain, SFM
Sarian, LO
Matos, J
Gontijo, R
Lima, T
Maeda, MYS
Tatti, S
Syrjanen, S
Syrjanen, K
Abstract: Purpose: To compare Hybrid Capture It (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples. Methods: Patients were submitted to Pap smears, Visual inspection with acetic acid (VIA) and HC2 for hr-HPV. Results: A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for an), cervical lesion and for CIN2 or higher were close to 90% in both groups. Conclusions: Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
Subject: hybrid capture
cervical cancer
liquid based cytology
Country: Canadá
Editor: I R O G Canada, Inc
Citation: European Journal Of Gynaecological Oncology. I R O G Canada, Inc, v. 29, n. 4, n. 327, n. 332, 2008.
Rights: fechado
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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