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Type: Artigo de periódico
Title: Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes
Author: Branco-de-Almeida, LS
Kajiya, M
Cardoso, CR
Silva, MJB
Ohta, K
Rosalen, PL
Franco, GCN
Han, XZ
Taubman, MA
Kawai, T
Abstract: Fluoxetine, one of the selective serotonin reuptake inhibitors (SSRIs), has been found to possess immune modulation effects, in addition to its antidepressant effects. However, it remains unclear whether SSRIs can suppress the antigen-presenting function of dendritic cells (DCs). Therefore, Fluoxetine was applied to a co-culture of Aggregatibacter actinomycetemcomitans (Aa)-reactive T cells (x Aa-T) isolated from Aa-immunized mice and DCs. This resulted in the suppressed proliferation of x Aa-T stimulated with Aa-antigen presentation by DCs. Specifically, Fluoxetine increased the extracellular 5-hydroxytryptamine (5-HT) in the x Aa-T/DC co-culture, whereas exogenously applied 5-HT promoted T-cell proliferation in the x Aa-T/DC co-culture, indicating that Fluoxetine-mediated suppression of x Aa-T/DC responses cannot be attributed to extracellular 5-HT. Instead, Fluoxetine remarkably suppressed the expression of costimulatory molecule ICOS-L on DCs. Fluoxetine also promoted a greater proportion of CD86(Low) immature DCs than CD86(High) mature DCs, while maintaining the expression levels of CD80, MHC-class-II and PD-L1. These results suggested that Fluoxetine suppressed the ability of DCs to present bacterial antigens to T cells, and the resulting T-cell proliferation, in a SERT/5-HT-independent manner and that diminished expression of ICOS-L on DCs and increase of CD86(Low) immature DCs caused by Fluoxetine might be partially associated with Fluoxetine-mediated suppression of DC/T-cell responses.
Subject: Fluoxetine
serotonin (5-HT)
dendritic cells
antigen presentation
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1111/j.1574-695X.2011.00816.x
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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