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Type: Artigo de periódico
Title: Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats
Author: Prada, PO
Pauli, JR
Ropelle, ER
Zecchin, HG
Carvalheira, JBC
Velloso, LA
Saad, MJA
Abstract: A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Subject: high-fat diet
adipose tissue
skeletal muscle
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2006.08.004
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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