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Type: Artigo de periódico
Title: Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom
Author: Costa, SKP
Moreno, RA
Esquisatto, LCM
Juliano, L
Brain, SD
De Nucci, G
Antunes, E
Abstract: The leukocyte migration induced by Phoneutria nigriventer spider venom (PNV) has been investigated in rats using the pleurisy model. Intrapleural injection of PNV (10-100 mug/cavity) caused a dose- and time-dependent leukocyte accumulation. The bradykinin B-2 receptor antagonist Hoe 140 (0.5 mg/kg) substantially inhibited PNV-induced cell accumulation, whereas the angiotensin-converting enzyme inhibitor captopril (2 mg/kg) potentiated by 80% this effect. The non-specific kallikrein inhibitor aprotinin and the plasma kallikrein inhibitor soybean trypsin inhibitor greatly reduced PNV-induced leukocyte migration, whereas the selective tissue kallikrein inhibitor P-ac-F-S-R-EDDnp failed to affect PNV-induced responses. Treatment of rats with capsaicin (50 mg/kg) at the neonatal stage resulted in 67% inhibition of the PNV-induced cell migration. The neurokinin NK1 receptor antagonist SR140333, but not the NK2 receptor antagonist SR48968, reduced by 55% venom-induced cell accumulation. We conclude that bradykinin generation is involved in the PNV-induced pleural leukocyte migration in rats, where it can directly activate sensory nerves contributing to a neurogenic inflammatory mechanism. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Subject: Phoneutria nigriventer venom
sensory neurons
Country: Irlanda
Editor: Elsevier Sci Ireland Ltd
Rights: fechado
Identifier DOI: 10.1016/S0304-3940(01)02498-3
Date Issue: 2002
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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