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Type: Artigo de periódico
Title: Role of adenosine triphosphate-dependent potassium channels in canine penile erection
Author: Cara, AD
Fregonesi, A
Antunes, E
De Nucci, G
Netto, NR
Abstract: Objectives. To define the physiologic role and hemodynamic features of nitric oxide (NO) and the adenosine triphosphate (ATP)-dependent K+ (K-ATP) channel in canine penile erection. Methods. Mongrel dogs were anesthetized, and penile erection was induced by electrical stimulation of the pelvic nerve. Changes in the intracavernous pressure (ICP) were measured with a transducer. Results. The basal ICP was 12.8 +/- 5.0 mm Hg. Pelvic nerve stimulation (5 to 20 V, 5 to 15 Hz, for 1-minute intervals) significantly increased the ICP to 86.2 +/- 11.4 mm Hg (n = 5, P < 0.05). Treatment with the NO synthase inhibitor N-&omega;-nitro-L-arginine methyl ester (110 mg/kg intravenously) abolished this increase (15.4 &PLUSMN; 5.0 mm Hg, n 5). Intracavernous injection of the K-ATP channel opener cromakalim (3 and 10 &mu;g) increased the ICP (103 &PLUSMN; 14.4 mm Hg and 106 &PLUSMN; 12.1 mm Hg, respectively; n = 4). This response was abolished by the prior intracavernous injection of the selective K-ATP channel-specific blocker glibenclamide (10 mg). Glibenclamide did not affect the increase in ICP induced by electric stimulation of the pelvic nerve (88 &PLUSMN; 24.2 mm Hg). Conclusions. Our results indicate that relaxation of canine cavernous smooth muscle and penile tumescence are mediated by NO. The failure of glibenclamide to affect the increase in ICP induced by pelvic nerve stimulation suggests that ATP-dependent K+ channels probably do not play a physiologic role in canine penile erection.
Country: EUA
Editor: Elsevier Science Inc
Rights: fechado
Identifier DOI: 10.1016/j.urology.2004.04.044
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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