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Type: Artigo de periódico
Title: Restriction Fragment Length Polymorphism of Urease C and Urease B Genes of Helicobacter pylori Strains Isolated from Brazilian Patients with Peptic Ulcer and Chronic Gastritis
Author: Roesler, BM
de Oliveira, TB
Bonon, SHA
Monici, LT
Zeitune, JMR
Costa, SCB
Abstract: The aim of the present work is to identify the presence of Helicobacter pylori bacterium in samples of gastric mucosa fragments, obtained by gastric biopsy, from Brazilian patients with peptic ulcer and chronic gastritis and also to determine differences among the prevalent strains in these two diseases by urease C and urease B genes amplification utilizing nested polymerase chain reaction (PCR) and PCR. We encountered 17 genotyping patterns for urease C and 7 for urease B and, although no significant differences were found among the patterns encountered for both diseases, we found predominant groups for each disease. Typing methods of the products obtained by nested PCR and PCR show a functional scheme and are of great importance for epidemiologic studies and H. pylori strain characterization, in addition to allowing correlation among the several strains and their role in the diseases caused by this microorganism.
Subject: Helicobacter pylori
Chronic gastritis
Peptic ulcer
Urease gene
Country: Holanda
Editor: Springer
Citation: Digestive Diseases And Sciences. Springer, v. 54, n. 7, n. 1487, n. 1493, 2009.
Rights: fechado
Identifier DOI: 10.1007/s10620-008-0525-2
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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