Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/71036
Type: Artigo de periódico
Title: RESPONSE OF DRUG-RESISTANT ISOLATES OF SCHISTOSOMA-MANSONI TO ANTISCHISTOSOMAL AGENTS
Author: DRESCHER, KM
ROGERS, EJ
BRUCE, JI
KATZ, N
DIAS, LCD
COLES, GC
Abstract: The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquine, and praziquantel) were evaluated in infected female Swiss albino mice. These schistosomal isolates had been maintained in the laboratory without further drug pressure for 2 0 to 30 generations. Multiple dosage regimens were used for each drug against each isolate of S. mansoni to generate ED50 (effective dose 50%) values. Results demonstrated that the K isolate is resistant to niridazole, the MPR-1 isolate to oxamniquine, and the MAP isolate to both hycanthone and oxamniquine. The BH isolate was susceptible to all drugs and was used as the reference isolate. All isolates were susceptible to praziquantel. The significance of the difference in response of the MPR-1 and MAP isolates is discussed. These results confirm the resistance of these isolates of S. mansoni to three schistosomicides and demonstrate that the resistance of these isolates are stable over long periods of time without exposure to drugs.
Subject: SCHISTOSOMA-MANSONI
DRUG-RESISTANCE
PRAZIQUANTEL
HYCANTHONE
OXAMNIQUINE
NIRIDAZOLE
SUSCEPTIBILITY
SCHISTOSOME ISOLATES (BH, MAP, K AND MPR-1)
Country: Brasil
Editor: Mem Inst Oswaldo Cruz
Rights: aberto
Date Issue: 1993
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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