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Type: Artigo de periódico
Title: Release of NO by a nitrosyl complex upon activation by the mitochondrial reducing power
Author: Toledo, JC
Lopes, LGD
Alves, AA
da Silva, LP
Franco, DW
Abstract: The reaction of trans-[Ru(NH3)(4)P(OEt)(3)NO](3+) and mitochondria was investigated through differential pulse polarography and fluorimetry. The nitrosyl complex undergoes one-electron reduction centered on the NO ligand site. The reaction between the mitochondrial reductor and trans- [Ru(NH3)(4)P(OEt)(3) NO](2+) exhibits a second order specific rate constant calculated as k=2x10(1) M-1 s(-1). The reduced species, trans- [Ru(NH3)(4)P(OEt)(3) NO](2+), quickly releases NO, yielding trans-[Ru(NH3)(4)P(OEt)(3)H2O](2+). The low toxicities of both trans- [Ru(NH3)(4)P(OEt)(3) (NO)](2+) and trans- [Ru(NH3)(4)P(OEt)(3)H2O](2+) and its ability to release NO after reductive activation in a biological medium make the nitrosyl compound a useful model of a hypotensive drug. (C) 2002 Elsevier Science Inc. All rights reserved.
Subject: nitrosyl
ruthenium complexes
Country: EUA
Editor: Elsevier Science Inc
Rights: fechado
Identifier DOI: 10.1016/S0162-0134(01)00414-7
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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