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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePolysaccharide-based hydrogels: Preparation, characterization, and drug interaction behaviourpt_BR
dc.contributor.authorVieira, EFSpt_BR
dc.contributor.authorCestari, ARpt_BR
dc.contributor.authorAiroldi, Cpt_BR
dc.contributor.authorLoh, Wpt_BR
unicamp.author.emaileunice@ufs.brpt_BR
unicamp.authorVieira, Eunice F. S. Cestari, Antonio R. Univ Fed Sergipe, Dept Quim, CCET, Lab Mat & Calorimetry, BR-49100000 Sao Cristovao, Brazilpt_BR
unicamp.authorAiroldi, Claudio Loh, Watson Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, Brazilpt_BR
dc.subject.wosIsothermal Calorimetrypt_BR
dc.subject.wosThermal-analysispt_BR
dc.subject.wosAgricultural Applicationspt_BR
dc.subject.wosChitosan Derivativespt_BR
dc.subject.wosSodium Alginatept_BR
dc.subject.wosMembranespt_BR
dc.subject.wosDegradationpt_BR
dc.subject.wosComplexespt_BR
dc.subject.wosPolymerspt_BR
dc.subject.wosKineticspt_BR
dc.description.abstractOxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl2, and their interactions with an antifolate drug, pyrimethamine (PYR), have been investigated. Tablets with a mean diameter of 1.2 +/- 0.06 cm were produced and drug interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC). From ITC responses, the enthalpy changes of interaction PYR/materials, Delta H-int, have been determined and were found to be - 11.73 +/- 0.517 kJ mol(-1) for ADA and -4.86 +/- 0.156 kJ mol(-1) for ADA-Chit. The PYR encapsulation of approximately 75% was achieved for both materials, as measured by UV spectrometer.pt
dc.relation.ispartofBiomacromoleculespt_BR
dc.relation.ispartofabbreviationBiomacromoleculespt_BR
dc.publisher.cityWashingtonpt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Chemical Socpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationAPRpt_BR
dc.identifier.citationBiomacromolecules. Amer Chemical Soc, v. 9, n. 4, n. 1195, n. 1199, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage1195pt_BR
dc.description.lastpage1199pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1525-7797pt_BR
dc.identifier.wosidWOS:000254983000016pt_BR
dc.identifier.doi10.1021/bm7011983pt_BR
dc.date.available2014-11-19T01:42:48Z
dc.date.available2015-11-26T17:55:50Z-
dc.date.accessioned2014-11-19T01:42:48Z
dc.date.accessioned2015-11-26T17:55:50Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T01:42:48Z (GMT). No. of bitstreams: 1 WOS000254983000016.pdf: 1773592 bytes, checksum: 8cbbaf8185b33206c48b7db00dd94efc (MD5) Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:55:50Z (GMT). No. of bitstreams: 2 WOS000254983000016.pdf: 1773592 bytes, checksum: 8cbbaf8185b33206c48b7db00dd94efc (MD5) WOS000254983000016.pdf.txt: 26906 bytes, checksum: 2004d6714419eb8d847e30d3b15a1e1f (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70773pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/70773
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70773-
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