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Type: Artigo de periódico
Title: Polysaccharide-based hydrogels: Preparation, characterization, and drug interaction behaviour
Author: Vieira, EFS
Cestari, AR
Airoldi, C
Loh, W
Abstract: Oxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl2, and their interactions with an antifolate drug, pyrimethamine (PYR), have been investigated. Tablets with a mean diameter of 1.2 +/- 0.06 cm were produced and drug interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC). From ITC responses, the enthalpy changes of interaction PYR/materials, Delta H-int, have been determined and were found to be - 11.73 +/- 0.517 kJ mol(-1) for ADA and -4.86 +/- 0.156 kJ mol(-1) for ADA-Chit. The PYR encapsulation of approximately 75% was achieved for both materials, as measured by UV spectrometer.
Country: EUA
Editor: Amer Chemical Soc
Citation: Biomacromolecules. Amer Chemical Soc, v. 9, n. 4, n. 1195, n. 1199, 2008.
Rights: fechado
Identifier DOI: 10.1021/bm7011983
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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