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Type: Artigo de periódico
Title: Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults
Author: Addas-Carvalho, M
de Paula, EV
Lima, CSP
Saad, STO
Abstract: Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respective products and related with inflammatory diseases. The aim of the present study was to investigate the association of polymorphisms of IL1B-511C/T and +3953C/T, IL1RN intron 2, IL6-174G/C and TNF-308G/A genes with CINA. We analysed 29 CINA and controls by polymerase chain reaction and restriction fragment length polymorphism. Statistical analyses were performed using chi(2) test, and the Hardy-Weinberg equilibrium (HWE) was investigated. All alleles analysed were in HWE in both populations. Similar frequencies of IL1B-511C/T, IL1B+3953C/T, IL1RN, IL6-174G/C and TNF-308G/A genotypes were observed in CINA and controls. These results suggest that cytokine polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of CINA and were not responsible for the increased cytokine in CINA patients.
Subject: chronic neutropenia
Country: EUA
Editor: Springer
Citation: Annals Of Hematology. Springer, v. 84, n. 11, n. 709, n. 714, 2005.
Rights: fechado
Identifier DOI: 10.1007/s00277-005-1066-9
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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