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Type: Artigo de periódico
Title: Polymorphisms in GABRB3 and Oral Clefting in the Brazilian Population
Author: Filezio, MR
Bagordakis, E
de Aquino, SN
Messetti, ACP
Martelli, H
Swerts, MSO
Graner, E
Coletta, RD
Paranaiba, LMR
Abstract: The aim of this study was to evaluate the influence of the gamma-aminobutyric acid receptor type A beta-3 subunit (GABRB3) polymorphisms in patients with nonsyndromic cleft lip and/or palate (NSCL/P). We carried out a structured case-control analysis of three GABRB3 polymorphisms (rs4477673, rs6576618, and rs981778) in 229 patients with nonsyndromic cleft lip with or without cleft palate (CL +/- P) and in 314 unaffected controls from Brazil. The polymorphisms were genotyped by the TaqMan 5'-exonuclease allelic discrimination assay, and each sample was independently typed for 40 biallelic short insertion/deletion markers (INDELs) to characterize the genomic ancestry. The genotype distributions of the three polymorphisms were as expected by the Hardy-Weinberg equilibrium test. After adjustment to ancestry contribution, the minor A allele of rs981778 was associated with NSCL/P, but significant results did not persist after Bonferroni correction for multiple tests. Similarly, the haplotype analysis revealed that the CCA haplotype (C allele of rs4477673, C allele of rs6576618, and A allele of rs981778) was correlated with NSCL/P, but this association did not remain statistically significant after Bonferroni correction. With a weak association, our data do not support the hypothesis that the GABRB3 variants are a cause of NSCL/P, but further studies are warranted.
Country: EUA
Editor: Mary Ann Liebert Inc
Citation: Dna And Cell Biology. Mary Ann Liebert Inc, v. 32, n. 3, n. 125, n. 129, 2013.
Rights: embargo
Identifier DOI: 10.1089/dna.2012.1925
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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