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Type: Artigo de periódico
Title: Polymorphisms GSTMI and GSTTI and sporadic breast cancer mammographic features
Author: Morais, LMTS
Cardoso, C
Lourenco, GJ
Shinzato, JY
Zeferino, LC
Lima, CSP
Gurgel, MSC
Abstract: INTRODUCTION. Enzymes of the Glutathione S-transferase system (GST) modulate the effects of exposure to several cytotoxic and genotoxic agents. The GSTMI and GSTTI genes are polymorphic in humans and their deletions have been associated to increased risk of many cancers, including breast cancer. OBJECTIVE: To evaluate the occurrence of homozygous deletions of the GSTMI and GSTTI genes in women with sporadic breast cancer and in women without cancer and to compare breast cancer mammographic features between patients with and without these deletions. METHODS: The study evaluated 100 patients with sporadic breast cancer treated from September 2004 to June 2005 and 169 women without cancer, determining the frequency of the above-mentioned deletions by PCR and calculating the odds ratios and their 95% confidence intervals. Medical files and mammograms of 100 patients with breast cancer were evaluated and correlated with mammographic features such as density, mammographic findings and the BI-RADS classification. These findings were correlated with the genetic deletions by the PR (Prevalence-Ratio) with their respective 95% confidence intervals. RESULTS: The GSTMI gene was deleted in 40% of the cancers and in 44.4% of controls(OR=1.20; CI 95% 0.70-2.04; p=05659) while the GSTTI gene was deleted in 20% and 19.5%, respectively(OR = 0.73;CI95% 0.37-1.44; p=0.4124). High mammographic density had been associated with GSTMI deletion (PR 2.43; CI 1.11 to 4.08). GST deletions were not associated with predominant mammographic findings and the BI-RADS classification. CONCLUSION: GSTMI homozygous deletion was associated with high mammographic density.
Subject: glutathione S-transferase
Country: Brasil
Editor: Assoc Medica Brasileira
Rights: aberto
Identifier DOI: 10.1590/S0104-42302008000100022
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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