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Type: Artigo de periódico
Title: Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B-12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children
Author: Alessio, ACM
Hoeehr, NF
Siqueira, LH
Bydlowski, SP
Annichino-Bizzacchi, JM
Abstract: One of the etiologies of hyperhomocysteinemia is decreased vitamin B-12. Genetic variation in the transcobalamin II gene, the transporter of vitamin B12 to the cells, may produce altered homocysteine levels. We determined transcobalamin 11 C776G polymorphism, homocysteine, folate and vitamin B12 levels and analyzed the interactive effect with the methylenetetrahydrofolate reductase C677T and A1298C and methionine synthase reductase A66G polymorphisms in 207 healthy Brazilian children. The prevalence of GG genotype of transcobalamin 11 C776G polymorphism in this Brazilian population, a highly miscigeneous population was 12.5% and the statistical analysis showed that this population is in Hardy-Weinberg equilibrium, it could be considered representative of the general population. We observed a significant increase in homocysteine in the 776GG vs. 776CC genotype, corroborating the influence of age as a determinant of homocysteine in relation to this polymorphism. When we analyzed vitamin B-12 and its relationship with the C776G polymorphism, we found no significant differences. Only 776CG/66AA or 776GG/66AG genotypes presented a significant increase in homocysteine when compared with other groups. In the multivariate analysis, transcobalamin II C776G (CC/CG vs. GG), methylenetetrahydrofolate reductase C677T (CC/CT vs. TT),,fotate, gender and age presented statistical significance in relation to the homocysteine. These can be considered independent risk factors for hyperhomocysteinemia in this children group. Our results, if confirmed in other populations, highlight the necessity for investigation of the transcobalamin 11 C776G polymorphism in the research for hyperhomocysteinemia risk factors. (c) 2006 Elsevier Ltd. All rights reserved.
Subject: homocysteine
transcobalamin II
methionine synthase reductase
methylenetetrahydro-folate reductase
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Thrombosis Research. Pergamon-elsevier Science Ltd, v. 119, n. 5, n. 571, n. 577, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.thromres.2006.05.009
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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