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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePolymeric alginate nanoparticles containing the local anesthetic bupivacainept_BR
dc.contributor.authorGrillo, Rpt_BR
dc.contributor.authorde Melo, NFSpt_BR
dc.contributor.authorde Araujo, DRpt_BR
dc.contributor.authorde Paula, Ept_BR
dc.contributor.authorRosa, AHpt_BR
dc.contributor.authorFraceto, LFpt_BR
unicamp.author.emailleonardo@sorocaba.unesp.brpt_BR
unicamp.authorGrillo, Renato de Melo, Nathalie F. S. Rosa, Andre Henrique Fraceto, Leonardo Fernandes Unesp Sao Paulo State Univ, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazilpt_BR
unicamp.authorde Melo, Nathalie F. S. de Paula, Eneida Univ Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, Brazilpt_BR
unicamp.authorde Araujo, Daniele Ribeiro Fed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP, Brazilpt_BR
dc.subjectBupivacainept_BR
dc.subjectpolymeric nanoparticlespt_BR
dc.subjectalginatept_BR
dc.subjectin vivopt_BR
dc.subjectin vitropt_BR
dc.subject.wosLoaded Biodegradable Nanospherespt_BR
dc.subject.wosSciatic-nerve Blockadept_BR
dc.subject.wosDrug-releasept_BR
dc.subject.wosQuantitative-determinationpt_BR
dc.subject.wosInclusion Complexpt_BR
dc.subject.wosDelivery Systemspt_BR
dc.subject.wosMatrix Tabletspt_BR
dc.subject.wosLidocainept_BR
dc.subject.wosMicroparticlespt_BR
dc.subject.wosNanocapsulespt_BR
dc.description.abstractBupivacaine (BVC; S75-R25, NovaBupi<SU (R)</SU) is an amide-type local anesthetic. Sodium alginate is a water-soluble linear polysaccharide. The present study reports the development of alginate/bis(2-ethylhexyl) sulfosuccinate (AOT) and alginate/chitosan nanoparticle formulations containing BVC (0.5%). The amounts of BVC associated in the alginate/AOT and alginate/chitosan nanoparticles were 87 +/- 1.5 and 76 +/- 0.9%, respectively. The average diameters and zeta potentials of the nanoparticles were measured for 30 days, and the results demonstrated the good stability of these particles in solution. The in vitro release kinetics showed a different behavior for the release profile of BVC in solution, compared with BVC-loaded alginate nanoparticles. In vitro and in vivo assays showed that alginate-chitosan BVC (BVC(ALG-CHIT)) and alginate-AOT BVC (BVC(ALG-AOT)) presented low cytotoxicity in 3T3-fibroblasts, enhanced the intensity, and prolonged the duration of motor and sensory blockades in a sciatic nerve blockade model.</.pt
dc.relation.ispartofJournal Of Drug Targetingpt_BR
dc.relation.ispartofabbreviationJ. Drug Target.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherInforma Healthcarept_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationJournal Of Drug Targeting. Informa Healthcare, v. 18, n. 9, n. 688, n. 699, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume18pt_BR
dc.description.issuenumber9pt_BR
dc.description.firstpage688pt_BR
dc.description.lastpage699pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdfpt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn1061-186Xpt_BR
dc.identifier.wosidWOS:000282516600005pt_BR
dc.identifier.doi10.3109/10611861003649738pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [06/00121-9]pt
dc.description.sponsordocumentnumberFUNDUNESP [06/00121-9, 07/00127-0, 08/01222-9]pt
dc.date.available2014-11-16T22:47:34Z
dc.date.available2015-11-26T16:25:49Z-
dc.date.accessioned2014-11-16T22:47:34Z
dc.date.accessioned2015-11-26T16:25:49Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:25:49Z (GMT). No. of bitstreams: 2 WOS000282516600005.pdf: 776545 bytes, checksum: 47314bddbccdef9f2c8854cecb5a538a (MD5) WOS000282516600005.pdf.txt: 57767 bytes, checksum: e27df5e6e8de3022e22f7bd41534a3aa (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70700pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/70700
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70700-
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