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Type: Artigo de periódico
Title: Polybioside, a Neuroactive Compound from the Venom of the Social Wasp Polybia paulista
Author: Saidemberg, DM
da Silva, LC
Tognoli, LMMC
Tormena, CF
Palma, MS
Abstract: Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Natural Products. Amer Chemical Soc, v. 73, n. 4, n. 527, n. 531, 2010.
Rights: fechado
Identifier DOI: 10.1021/np900424t
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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