Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/70668
Type: Artigo de periódico
Title: Polyarteritis nodosa and cytomegalovirus: Diagnosis by polymerase chain reaction
Author: Fernandes, SRM
Bertolo, MB
Rossi, CL
Samara, AM
Bonon, SHA
Durante, P
Costa, SCB
Abstract: We investigated the occurence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV Ige and anti-CMV IgM antibodies were determined by enzyme-linked immunosorbent assays (ELISA). The ELISA for IgM was negative in all cases whereas that for IgG was positive in eight cases. Only one patient was positive for CMV-DNA by PCR. He presented with myalgia, polyarthralgia, fever and weight loss, suggesting PAN activity. CMV infection was uncommon in our series of patients with PAN, despite disease activity and immunosuppressor therapy. The finding of a transient CMV infection in one case at the beginning of PAN activity suggests that CMV may be involved in the pathogenesis of PAN.
Subject: cytomegalovirus
polyarteritis nodosa
vasculitis
Country: EUA
Editor: Springer Verlag
Rights: fechado
Identifier DOI: 10.1007/s100670050148
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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