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Type: Artigo de periódico
Title: Epidemiologic aspects and clinical outcome of fungal keratitis in southeastern Brazil
Author: IBRAHIM, Marlon Moraes
VANINI, Rafael
IBRAHIM, Fuad Moraes
FURLAN, Eloisa M. R.
CASTRO, Rosane S. De
SOUSA, Sidney Julio de Faria e
ROCHA, Eduardo Melani
Abstract: PURPOSE. Fungal keratitis (FK) is a sight-threatening disease, more prevalent in developing regions. The present retrospective study was conducted in order to evaluate the epidemiologic and clinical aspects and the progression of FK in patients treated at two ophthalmologic reference centers in Southeast Brazil. METHODS. The charts of patients with infectious keratitis treated between 2000 and 2004 were reviewed. For the 66 cases of FK confirmed by microbiological analysis, data related to patient, disease, and therapeutic approaches were obtained. RESULTS. Mean patient age was 40.7 +/- 16 years. Fifty-three were men and 13 were women. Ocular trauma occurred in 40% of cases (27). Previous medications taken by the patients were quinolone in 72.5% and antimycotics in 30%. Visual acuity (VA) at presentation was >0.3 in 16% and <0.1 in 74.5%. Penetrant keratoplasty was performed in 38% and evisceration in 15%. The causing agents were Fusarium sp in 67%, Aspergillus sp in 10.5%, and Candida sp in 10%. Medication alone resolved 39% of cases within a mean period of 24.5 +/- 12 days. Final VA was >0.3 in 28%, and <0.1 in 63%. CONCLUSIONS. Fungal keratitis presented as a disease with severe complications, predominantly among young males, and was mostly caused by filamentous fungi. The present information permits the establishment of preventive strategies. Reducing the time between onset and treatment and using more accessible specific medication would reverse the negative prognosis. (Eur J Ophthalmol 2009; 19: 355-61)
Subject: Fusarium sp
Penetrant keratoplasty
Microbial keratitis
Blindness prevention
Country: Itália
Citation: EUROPEAN JOURNAL OF OPHTHALMOLOGY, v.19, n.3, p.355-361, 2009
Rights: fechado
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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