Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/70576
Type: Artigo de periódico
Title: Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia
Author: de Mendonca, RMH
de Araujo, M
Levy, CE
Morari, J
Silva, RA
Yunes, JA
Brandalise, SR
Abstract: Background Oral mucositis is a common collateral effect among the secondary complications resulting from chemotherapy. The objective of this study was to prospectively evaluate the association of HSV-1, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia (ALL). Procedure Seventy-one prospective patients were included. Analyses of oral microbiota were conducted on days 14 (D14) and 56 (D56) of the Brazilian GBTLI-99 treatment protocol. Herpes simplex virus (HSV) identification was performed by PCR followed by DNA sequencing analysis. Bacteria and fungi identification was obtained by standard microbiological culture tests. Results HSV-1 was found in 10.37% of individual patient samples. One sample was positive for HSV-4. On D14, we found an association between the severity of mucositis and the presence of HSV (p=0.0347) and Candida spp. (p=0.0078). At D56, we found an association between the severity of mucositis and the presence of HSV on D14 (p<0.0001) and HSV presence (p=0.0317). Conclusion The presence of HSV, mainly HSV-1, and Candida spp. was associated with mucositis severity in pediatric ALL. No association could be found between bacterial CFU and severity of mucositis.
Subject: Oral mucositis
Acute lymphoblastic leukemia
Oral bacteria
Herpes virus
Candida spp.
Country: EUA
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s00520-011-1190-0
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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